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Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures.

International League Against Epilepsy (ILAE)2023Full text
  • Communicating with families
  • Hypoxic-ischaemic encephalopathy and cooling
  • Medical
  • Neurology
  • Nursing
  • Seizures

Summary

International guideline from the ILAE Neonatal Task Force on antiseizure medication management in neonates, developed through systematic review, meta-analysis, GRADE assessment and Delphi consensus where evidence was lacking. It addresses first- and second-line drug choice, including considerations for suspected channelopathy and cardiac disorders, and discontinuation of medication before discharge after acute provoked seizures. It also covers the role of therapeutic hypothermia in reducing seizure burden in hypoxic-ischaemic encephalopathy, treatment of electrographic-only seizures, and a pyridoxine trial for suspected vitamin B6-dependent epilepsy. Additional themes include standardised unit pathways and informing parents about diagnosis and treatment.

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