Management of neonates at risk of early onset sepsis: a probability-based approach and recent literature appraisal : Update of the Swiss national guideline of the Swiss Society of Neonatology and the Pediatric Infectious Disease Group Switzerland.

Summary

Updated Swiss national guideline from the Swiss Society of Neonatology and the Pediatric Infectious Disease Group Switzerland on managing term, late preterm and preterm neonates at risk of early onset sepsis. It promotes a probability-based approach, using serial physical examination rather than the EOS calculator, with the aim of safely reducing unnecessary antibiotic exposure and antimicrobial resistance. It covers blood culture practice, indications for lumbar puncture, the limited role of biomarkers and PCR, empirical antibiotic choice, early cessation of antibiotics, and assessment and support of organ dysfunction and septic shock.

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