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Congenital Syphilis (CDC Sexually Transmitted Infections Treatment Guidelines, 2021)

Centers for Disease Control and Prevention (CDC)2021Full text
  • Congenital infections
  • Infection
  • Medical
  • Nursing

Summary

This CDC guideline section addresses the rising incidence of congenital syphilis in the United States and the role of antenatal serological screening in prevention. It sets out maternal risk factors, documentation of maternal serostatus before discharge, and the interpretation of neonatal nontreponemal testing compared with maternal titres. Neonatal evaluation and treatment are structured into scenarios ranging from proven or highly probable to unlikely congenital syphilis, with recommended investigations and penicillin-based regimens. It applies to clinicians caring for pregnant women and newborns exposed to maternal syphilis.

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