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Guideline · Consensus statement

Pain management in preterm infants with necrotizing enterocolitis: an international expert consensus statement.

Consensus statementEuropean Society for Paediatric Research (ESPR)2025Full text
  • Comfort and nursing care
  • Medical
  • Necrotising enterocolitis
  • Nursing
  • Nutrition and gastrointestinal
  • Pain and comfort
  • Surgical conditions

Summary

International expert consensus statement from ESPR Special Interest Groups on Neonatal Pain and NEC addressing pain assessment and treatment in preterm infants with necrotising enterocolitis. Developed through an online survey and two consensus meetings with voting, it presents nine recommendations. Themes include regular pain assessment using a validated neonatal pain scale, additional assessments when indicated, and pre-emptive analgesic therapy (e.g. paracetamol and an opioid) in infants with NEC stage II or above. It aims to reduce variability in analgesic practice for this vulnerable population.

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