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Guideline

Clinical Overview of Perinatal Hepatitis B

Centers for Disease Control and Prevention (CDC)2025Sept. 18, 2025Full text
  • Congenital infections
  • Infection
  • Infection prevention
  • Medical
  • Neurodevelopmental follow-up
  • Nursing
  • Postnatal and transitional care

Summary

This CDC clinical overview covers perinatal hepatitis B virus transmission from HBsAg-positive pregnant patients to their infants. It outlines antenatal HBsAg screening, maternal HBV DNA testing and antiviral therapy, and postexposure immunoprophylaxis with hepatitis B vaccine and HBIG within 12 hours of birth. It describes vaccine schedules by birth weight, post-vaccination serologic testing, parent counselling and the US Perinatal Hepatitis B Prevention Program. It is aimed at clinicians caring for pregnant patients and newborns in the United States.

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