Journal Club - What did two Dutch NICUs learn from routine probiotics in preterm infants?
The Incubator Channel · 30 Sept 2026 · 20 min
Summary
A journal club discussion of a JAMA Network Open before-and-after study from two Dutch Level IV NICUs on routine three-strain probiotic use in infants born before 30 weeks or under 1,000 grams, covering reductions in NEC and late-onset sepsis alongside a rise in non-NEC mortality and a B. infantis sepsis death. The presenters discuss how baseline NEC rates, seasonal patterns, a falling NEC rate in an unexposed reference cohort and number needed to harm should inform unit decisions on probiotics.
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