🟠 CHNC 2025 KEYNOTE - Acetaminophen and the lung - FUND THE SCIENCE Acetaminophen and the lung
The Incubator Channel · 11 Nov 2025 · 13 min
Summary
A CHNC 2025 keynote in which Dr Clyde Wright examines the rapid rise of acetaminophen (paracetamol) for ductal closure in preterm infants, despite limited long-term safety data, and how its CYP2E1-generated reactive metabolite may affect mitochondrial function in developing lung cells. He urges judicious use, particularly outside optimal treatment windows, and calls for research that includes respiratory outcomes and individualised risk–benefit discussions.
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