🟢 HOT TOPICS 2025 COVERAGE - Discussing the results of the PDA trial with Dr. Matthew Laughon
The Incubator Channel · 9 Dec 2025 · 17 min
Summary
Dr Matthew Laughon presents the results of the NICHD Neonatal Research Network PDA Management Trial comparing expectant management with active medical treatment (indomethacin, ibuprofen or acetaminophen) in preterm infants with symptomatic PDA. He discusses the early stopping for futility and safety, the higher mortality in the treatment group, the lack of difference in BPD, NEC and ROP, and the implications for expectant management.
Third-party teaching is shown for education. Check it against your unit's guidance.