Journal Club - Surfactant Thresholds: Is 40% FiO2 as Safe as 30%?
The Incubator Channel · 10 Feb 2026 · 13 min
Summary
Ben and Daphna review a non-inferiority trial from India comparing 30% versus 40% FiO2 thresholds for surfactant administration in preterm babies of 26-32 weeks' gestation, including surprising findings on respiratory support duration in younger subgroups. They also discuss rigid FiO2 cut-offs versus individualised assessment, how resource availability shapes protocols, and the role of LISA in avoiding intubation.
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