Journal Club - Prophylactic Acetaminophen for PDA, Does Early Closure Improve Outcomes?
The Incubator Channel · 9 Mar 2026 · 20 min
Summary
Ben and Daphna of The Incubator podcast review the TREOCAPA trial of prophylactic acetaminophen (paracetamol) for PDA closure in extremely preterm infants, covering dosing regimens, safety outcomes such as cholestasis, and why higher early closure rates did not improve survival without severe morbidity. They also discuss individualising PDA management and briefly touch on conducting research in private practice.
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