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Journal Club - 8 Days vs. 14 Days: Can We Shorten Antibiotics for Gram-Negative Sepsis?

The Incubator Channel · 24 Feb 2026 · 20 min

Summary

Ben and Daphna review a retrospective cohort study from Pediatrics comparing short (≤8 days) versus long (≥9 days) antibiotic courses for uncomplicated Gram-negative bloodstream infections in the NICU. They discuss findings of similar recurrence rates but more multi-drug resistant infections within 90 days in the long-course group, and implications for antibiotic stewardship.

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