Journal Club - After HEAL Does a Second Trial Close the Book on EPO?
The Incubator Channel · 1 Sept 2026 · 20 min
Summary
A journal club discussion of the PAEAN trial, a phase three multicentre trial of high-dose erythropoietin as an adjunct to therapeutic hypothermia for HIE in late preterm and term infants, comparing its findings with the earlier HEAL trial. The hosts discuss the two-year outcome of death or moderate to severe developmental deficit, the thrombosis signal, the value of replication trials in neonatology and remaining adjunct therapies.
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