Evidence · Systematic review or meta-analysis
Effects of therapeutic hypothermia on death among asphyxiated neonates with hypoxic-ischemic encephalopathy: A systematic review and meta-analysis of randomized control trials.
- Hypoxic-ischaemic encephalopathy and cooling
- Medical
- Neurology
- Nursing
Summary
This systematic review and meta-analysis pools 28 randomised controlled trials (about 3,592 infants) to estimate the effect of therapeutic hypothermia on mortality in birth-asphyxiated neonates with hypoxic-ischaemic encephalopathy. Subgroup analyses compare country income level, selective head versus whole-body cooling, and cooling devices. The authors report that hypothermia reduces mortality in moderate to severe HIE with both cooling methods. They conclude that low-income countries benefit most and should offer cooling routinely.
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- Licence:
- Open (Creative Commons)
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