Evidence · Randomised trial
Non-invasive duo positive airway pressure ventilation versus nasal continuous positive airway pressure in preterm infants with respiratory distress syndrome: a randomized controlled trial.
- CPAP and high flow
- Mechanical ventilation
- Medical
- Nursing
- Pneumothorax and air leak
- Respiratory
- Respiratory distress syndrome and surfactant
Summary
Single-centre randomised controlled trial from Ahwaz, Iran, comparing non-invasive duo positive airway pressure (N-DUOPAP) with nasal CPAP in 148 preterm infants of 28 to 34 weeks' gestation with respiratory distress syndrome. The primary outcome was treatment failure within the first 72 hours, with no significant difference between groups. N-DUOPAP was associated with shorter non-invasive ventilation and oxygen therapy, fewer repeat surfactant doses and shorter hospital stay. Rates of PDA, pneumothorax, IVH, BPD, apnoea and mortality did not differ significantly between groups.
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