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Evidence · Systematic review or meta-analysis

Human milk and neurodevelopment in children with very low birth weight: a systematic review.

Systematic review or meta-analysisNutrition Journal2014Over 5 years oldFull text
  • Allied health
  • Breast milk and breastfeeding
  • Enteral feeding
  • Medical
  • Neurodevelopmental follow-up
  • Neurology
  • Nursing
  • Nutrition and gastrointestinal

This paper is from 2014, more than five years ago. Newer evidence may have been published since.

Summary

This systematic review examines whether human milk feeding has a reproducible independent effect on neurodevelopmental outcomes in preterm very low birth weight infants. Of 24 studies identified, seven VLBW-only studies were reviewed and appraised against non-nutritive and nutritive methodological parameters, with outcomes assessed in early childhood and at school age. Human milk-fed VLBW children without neurological impairment achieved normal or low-normal test scores, while feeding with older formula formulations was associated with lower subtest scores in some studies. The authors note the absence of randomised trials in VLBW-only populations and call for high-quality studies using current fortifiers and preterm formulas.

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