Evidence · Systematic review or meta-analysis
Meta-analysis of diagnostic accuracy of neutrophil CD64 for neonatal sepsis.
- Early-onset sepsis
- Infection
- Late-onset sepsis
- Medical
- Neonatal transport
- Transport
This paper is from 2016, more than five years ago. Newer evidence may have been published since.
Summary
Systematic review and meta-analysis of 17 studies (3478 participants) evaluating neutrophil CD64 expression as a diagnostic marker for neonatal sepsis. It pools sensitivity, specificity, likelihood ratios and diagnostic odds ratio, with subgroup analyses by gestation and proven versus clinical infection. Performance was better in term infants and proven infection. The authors conclude nCD64 alone is not a satisfactory diagnostic marker and should be interpreted with caution.
Summary written for NICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
The full text of this openly licensed paper is available to NICUlearn members, and Neeky can answer questions from it.
Guidelines are shown for education. Follow your unit's own guidance and senior advice.