Evidence · Systematic review or meta-analysis
Prenatal exposure to antidepressants and persistent pulmonary hypertension of the newborn: systematic review and meta-analysis.
- Cardiovascular
- Medical
- Persistent pulmonary hypertension
- Respiratory
This paper is from 2014, more than five years ago. Newer evidence may have been published since.
Summary
Systematic review and meta-analysis of seven studies examining whether antenatal antidepressant exposure is associated with persistent pulmonary hypertension of the newborn. Quantitative analysis was possible only for SSRIs: late-pregnancy exposure was associated with increased risk, whereas early-pregnancy exposure was not. The absolute risk remained low, with an estimated 286 to 351 women needing late-pregnancy SSRI treatment for one additional case. Useful for neonatal and perinatal clinicians counselling families and anticipating PPHN in exposed infants.
Summary written for NICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
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