Evidence · Research paper
Biochemical profiles and organ dysfunction in neonates with hypoxic-ischemic encephalopathy post-hoc analysis of the THIN trial.
- Acute kidney injury
- Fluids and electrolytes
- Hypoxic-ischaemic encephalopathy and cooling
- Jaundice and haematology
- Medical
- Metabolic, endocrine and renal
- Neurology
- Nursing
- Thrombocytopenia and bleeding
Summary
Post-hoc secondary analysis of the THIN single-centre randomised controlled trial in India comparing biochemical profiles and organ dysfunction in 50 infants with moderate to severe hypoxic-ischaemic encephalopathy randomised to therapeutic hypothermia or normothermia. Outcomes included metabolic acidosis, coagulopathy, renal function and supportive treatments during the intervention. Cooled infants had slightly lower pH but better renal function in the first day, supporting the safety of cooling in a level III unit. The authors highlight the need to define the level of intensive care required for cooling in low-resource settings.
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- Open (Creative Commons)
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