Evidence · Systematic review or meta-analysis
Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies.
- Cardiovascular
- Medical
- Necrotising enterocolitis
- Nursing
- Nutrition and gastrointestinal
- Shock and hypotension
This paper is from 2017, more than five years ago. Newer evidence may have been published since.
Summary
This systematic review identifies independent prognostic factors for necrotising enterocolitis in neonates from cohort studies using multivariable analysis, with quality assessed using the QUIPS tool. Fourteen studies were included, most of moderate or low quality, and meta-analysis was not feasible. Factors reported in at least two studies included low birth weight, small for gestational age, low gestational age, assisted ventilation, prolonged rupture of membranes, black ethnicity, sepsis, outborn status and hypotension, with caesarean section associated with lower risk and surfactant showing conflicting results. The authors highlight the scarcity of high-quality prognostic research and the need for further work to establish predictive values.
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- Licence:
- Open (Creative Commons)
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