Evidence · Research paper
Association of Fluid Balance With Short- and Long-term Respiratory Outcomes in Extremely Premature Neonates: A Secondary Analysis of a Randomized Clinical Trial.
- Anaemia and transfusion
- Bronchopulmonary dysplasia
- Fluids and electrolytes
- Jaundice and haematology
- Mechanical ventilation
- Medical
- Metabolic, endocrine and renal
- Nursing
- Respiratory
Summary
Secondary analysis of the PENUT trial cohort of 874 extremely preterm neonates born at 24 to 27 weeks' gestation across 30 US neonatal units, describing fluid balance patterns (percent change from birth weight) over the first 14 postnatal days. It examines the association of peak fluid balance with mechanical ventilation on day 14 and with severe bronchopulmonary dysplasia or death. Higher peak positive fluid balance was associated with worse respiratory outcomes. Fluid balance in the first three days and time to regain birth weight are proposed as potential management targets.
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- Open (Creative Commons)
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