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Evidence · Systematic review or meta-analysis

Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of Women at Risk of Imminent Preterm Birth: A Systematic Review and Meta-Analysis.

Systematic review or meta-analysisPLOS ONE2016Over 5 years oldFull text
  • Delivery room and stabilisation
  • Early-onset sepsis
  • Intraventricular haemorrhage and white matter injury
  • Medical
  • Neurology
  • Preterm stabilisation
  • Respiratory
  • Respiratory distress syndrome and surfactant

This paper is from 2016, more than five years ago. Newer evidence may have been published since.

Summary

This systematic review and meta-analysis examines antenatal corticosteroid use in special populations of women at risk of imminent preterm birth, including those with diabetes, elective late-preterm caesarean section, chorioamnionitis and fetal growth restriction. No eligible studies were found for diabetic women or elective late-preterm caesarean section. In chorioamnionitis, pooled data suggested reduced neonatal mortality, respiratory distress syndrome and intraventricular haemorrhage, while effects in fetal growth restriction were inconclusive. The authors highlight gaps in maternal and long-term child outcome data.

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