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Evidence · Review article

Prevention and Treatment of Neonatal Infections in Facility and Community Settings of Low- and Middle-Income Countries: A Descriptive Review.

Review articleNeonatology2025Full text
  • Cord management
  • Early-onset sepsis
  • Infection
  • Infection prevention
  • Late-onset sepsis
  • Line and device care
  • Medical
  • Necrotising enterocolitis
  • Nursing
  • Nutrition and gastrointestinal
  • Postnatal and transitional care
  • Skin care

Summary

Descriptive review synthesising evidence on interventions to prevent and treat newborn infections in low- and middle-income countries across facility, mixed and community settings. Prevention strategies covered include antimicrobial stewardship, healthcare-associated infection bundles, clean birth kits, chlorhexidine cord cleansing, emollients, probiotics and synbiotics. Treatment approaches include prophylactic antifungals and community-based antibiotic delivery for possible serious bacterial infection. It highlights evidence gaps where further randomised trials are needed.

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Open (Creative Commons)

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