Evidence · Systematic review or meta-analysis
Preterm Brain Injury and Neurodevelopmental Outcomes: A Meta-analysis.
- Allied health
- Intraventricular haemorrhage and white matter injury
- Medical
- Neurodevelopmental follow-up
- Neurology
- Nursing
Summary
This systematic review and meta-analysis of 38 observational studies (2000–2021) examines neurodevelopmental outcomes around three years of age in preterm infants with intraventricular haemorrhage or white matter injury, compared with uninjured preterm peers. Both mild and severe IVH were associated with increased risk of moderate–severe neurodevelopmental impairment, including cerebral palsy, cognitive, hearing and visual impairment. White matter injury carried particularly high risks of cerebral palsy, motor and cognitive impairment. The authors note heterogeneity of outcome data and call for core outcome sets and open-access data.
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- Licence:
- Open (Creative Commons)
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