Evidence · Randomised trial
Real-time continuous glucose monitoring in preterm infants (REACT): an international, open-label, randomised controlled trial.
- Fluids and electrolytes
- Hypoglycaemia
- Medical
- Metabolic, endocrine and renal
- Nursing
Summary
The REACT trial was an international, open-label randomised controlled trial in 13 NICUs in the UK, Spain and the Netherlands evaluating real-time continuous glucose monitoring (CGM) in very low birthweight preterm infants within 24 hours of birth. It compared real-time CGM with standard care (with masked CGM) for time spent in the target glucose range. Real-time CGM increased time in the target range and reduced prolonged hypoglycaemia exposure, without device-related serious adverse events or infection. The authors call for further work on optimal glucose targets and long-term outcomes.
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- Open (Creative Commons)
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