Evidence · Systematic review or meta-analysis
Neonatal and long-term outcomes of infants with congenital cytomegalovirus infection and negative amniocentesis: systematic review and meta-analysis.
- Congenital infections
- Eyes and hearing
- Infection
- Medical
- Neurodevelopmental follow-up
- Neurology
- Newborn hearing screening
Summary
This systematic review and meta-analysis of seven observational studies compares outcomes of pregnancies with maternal cytomegalovirus infection according to whether amniocentesis was negative or positive for CMV DNA. It examines the false-negative rate of amniocentesis, severe symptoms at birth, severe sensorineural hearing loss and neurodevelopmental impairment at follow-up, and termination for CMV-associated findings. Infants with congenital CMV despite a negative amniocentesis had no severe symptoms at birth or severe long-term sequelae. It is relevant to fetal medicine, neonatal and follow-up clinicians counselling families about congenital CMV.
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- Licence:
- Open (Creative Commons)
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