Evidence · Randomised trial
Inflammatory Mediators in Tracheal Aspirates of Preterm Infants Participating in a Randomized Trial of Inhaled Nitric Oxide.
- Bronchopulmonary dysplasia
- Cardiovascular
- Mechanical ventilation
- Medical
- Persistent pulmonary hypertension
- Respiratory
This paper is from 2017, more than five years ago. Newer evidence may have been published since.
Summary
Secondary analysis within the European multicentre EUNO randomised trial of inhaled nitric oxide versus placebo gas in ventilated extremely preterm infants (24–28 weeks). Serial tracheal aspirates from 43 infants were analysed for inflammatory and fibrotic mediators between postnatal days 2 and 14. Inhaled nitric oxide transiently reduced several markers associated with BPD development, although survival without BPD was not affected in the main trial. Of interest mainly for understanding lung inflammation mechanisms in BPD.
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- Open (Creative Commons)
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