Evidence · Randomised trial
Gut microbiota of preterm infants supplemented with probiotics: sub-study of the ProPrems trial.
- Enteral feeding
- Medical
- Necrotising enterocolitis
- Nursing
- Nutrition and gastrointestinal
This paper is from 2018, more than five years ago. Newer evidence may have been published since.
Summary
This sub-study of the ProPrems multicentre, double-blind, placebo-controlled randomised trial examined the gut microbiota of very preterm infants born before 32 weeks' gestation who received probiotic supplementation (BB-02, TH-4 and BB-12) from soon after birth. The parent trial had reported a reduction in Bell stage 2 or greater necrotising enterocolitis. Infants receiving probiotics had a substantially higher abundance of Bifidobacterium. The authors suggest early Bifidobacterium colonisation may be associated with reduced NEC risk.
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- Licence:
- Open (Creative Commons)
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