Evidence · Randomised trial
Phenobarbital versus morphine in the management of neonatal abstinence syndrome, a randomized control trial.
- Comfort and nursing care
- Medical
- Neonatal abstinence syndrome
- Nursing
- Postnatal and transitional care
This paper is from 2015, more than five years ago. Newer evidence may have been published since.
Summary
This open-label randomised controlled trial from two hospitals in Tehran, Iran, compared oral morphine sulfate with a loading and tapering dose of phenobarbital in 60 neonates born to drug-dependent mothers who had neonatal abstinence syndrome requiring medical therapy. Outcomes were duration of treatment to resolution, total hospital stay and need for adjunctive second-line treatment. No significant differences were found between the groups on any outcome. It is relevant to clinicians choosing first-line pharmacological treatment for NAS.
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- Licence:
- Open (Creative Commons)
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