Evidence · Research paper
Genotypic study documents divergence in the pathogenesis of bloodstream infection related central venous catheters in neonates.
- Comfort and nursing care
- Infection
- Infection prevention
- Late-onset sepsis
- Line and device care
- Medical
- Nursing
This paper is from 2014, more than five years ago. Newer evidence may have been published since.
Summary
Prospective cohort study from a Brazilian neonatal unit investigating the pathogenesis of Staphylococcus epidermidis bloodstream infection in high-risk neonates with central venous catheters in place for more than 24 hours. Surveillance followed National Healthcare Safety Network methods, with DNA fingerprinting and multiplex-PCR detection of mecA and icaAD genes. Most infections had an unknown origin, with some attributed to intraluminal or extraluminal acquisition, and a predominant clone was identified among resistant, biofilm-gene-positive isolates. Relevant to understanding catheter-related infection and line care practices.
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