Evidence · Systematic review or meta-analysis
Efficacy and Safety of Levetiracetam vs. Phenobarbital for Neonatal Seizures: A Systematic Review and Meta-Analysis.
- Cardiovascular
- Medical
- Neurology
- Seizures
- Shock and hypotension
Summary
This systematic review and meta-analysis of ten studies compares levetiracetam with phenobarbital for treating neonatal seizures. It assesses efficacy, side effects, neurodevelopmental outcomes (Bayley scores) and mortality. No difference in seizure control was found, but levetiracetam was associated with fewer adverse effects, notably hypotension and respiratory depression. The authors note phenobarbital remains WHO-recommended first-line therapy and advocate continuous EEG monitoring for diagnosis and assessing treatment response.
Summary written for NICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
The full text of this openly licensed paper is available to NICUlearn members, and Neeky can answer questions from it.
Guidelines are shown for education. Follow your unit's own guidance and senior advice.