Association of patent ductus arteriosus treatment in extremely low gestational age neonates with two year kidney outcomes: a secondary analysis of the preterm erythropoietin neuroprotection trial (PENUT).

Summary

Secondary analysis of the PENUT trial cohort examining whether treatment of patent ductus arteriosus in extremely low gestational age neonates is associated with kidney dysfunction at two years of age. Of 780 infants, 43% were treated for PDA, mostly pharmacologically, with some receiving surgical ligation. After adjustment, treated infants were less likely to have elevated systolic blood pressure at two years, while other kidney outcomes such as eGFR and proteinuria did not differ. The authors call for prospective studies on haemodynamically significant PDA management and long-term renal outcomes.

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