Evidence · Systematic review or meta-analysis
International treatment outcomes of neonates on extracorporeal membrane oxygenation (ECMO) with persistent pulmonary hypertension of the newborn (PPHN): a systematic review.
- Cardiovascular
- Congenital diaphragmatic hernia
- Mechanical ventilation
- Meconium aspiration
- Medical
- Persistent pulmonary hypertension
- Respiratory
Summary
Systematic review of 134 studies (2010–2023) including 1,814 neonates with persistent pulmonary hypertension of the newborn treated with ECMO, comparing survivors with non-survivors. It examines demographic factors, underlying aetiologies such as congenital diaphragmatic hernia, meconium aspiration and respiratory distress syndrome, comorbidities, and ECMO-related complications. Overall survival was around two-thirds, with higher mortality associated with lower Apgar scores, certain aetiologies and comorbidities, longer ventilation and ECMO duration, and complications such as intracranial bleeding and chylothorax.
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- Open (Creative Commons)
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