Evidence · Systematic review or meta-analysis
Amplitude Integrated Electroencephalogram as a Prognostic Tool in Neonates with Hypoxic-Ischemic Encephalopathy: A Systematic Review.
- Communicating with families
- Hypoxic-ischaemic encephalopathy and cooling
- Medical
- Neurodevelopmental follow-up
- Neurology
- Nursing
This paper is from 2016, more than five years ago. Newer evidence may have been published since.
Summary
Systematic review and meta-analysis of 17 studies assessing the prognostic value of amplitude-integrated EEG (aEEG) background activity in neonates with hypoxic-ischaemic encephalopathy, with neurodevelopmental follow-up of at least 12 months. Results are separated by whether infants received therapeutic hypothermia and by hours of life at recording. Predictive reliability of an abnormal background peaked earlier in non-cooled infants and later, at around 72 hours, in cooled infants, with early recordings being less predictive under hypothermia. Findings support the use of serial aEEG over the first 72 hours to inform prognosis and parental counselling.
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