Evidence · Systematic review or meta-analysis
Inhaled nitric oxide in premature infants for preventing bronchopulmonary dysplasia: a meta-analysis.
- Bronchopulmonary dysplasia
- Cardiovascular
- Intraventricular haemorrhage and white matter injury
- Mechanical ventilation
- Medical
- Necrotising enterocolitis
- Neurology
- Nutrition and gastrointestinal
- Persistent pulmonary hypertension
- Respiratory
Summary
This meta-analysis of 11 randomised controlled trials examines whether inhaled nitric oxide reduces bronchopulmonary dysplasia in preterm infants of 34 weeks' gestation or less who require respiratory support. It compares outcomes by initial dose and assesses safety outcomes, including necrotising enterocolitis, in-hospital mortality, severe intraventricular haemorrhage or periventricular leukomalacia, and pulmonary haemorrhage. The authors report a modest overall reduction in BPD, with differences in effect and NEC risk between initial dosing strategies. It is relevant to clinicians weighing the evidence on iNO use in preterm respiratory care.
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- Licence:
- Open (Creative Commons)
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