Evidence · Randomised trial
Humidified High Flow Nasal Cannula versus Nasal Continuous Positive Airway Pressure as an Initial Respiratory Support in Preterm Infants with Respiratory Distress: a Randomized, Controlled Non-Inferiority Trial.
- CPAP and high flow
- Mechanical ventilation
- Medical
- Nursing
- Preterm stabilisation
- Respiratory
- Respiratory distress syndrome and surfactant
This paper is from 2017, more than five years ago. Newer evidence may have been published since.
Summary
This randomised controlled non-inferiority trial compared heated humidified high-flow nasal cannula with nasal CPAP as initial respiratory support for preterm infants of 30 to 35 weeks' gestation with respiratory distress within 24 hours of birth. The primary outcome was treatment failure requiring intubation or mechanical ventilation. Treatment failure was numerically more frequent with high flow, with hypoxia a more common reason for failure, though other respiratory outcomes and complications were similar. The authors concluded high flow appeared safe but non-inferiority to CPAP as initial support was not established.
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- Open (Creative Commons)
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