Evidence · Systematic review or meta-analysis
Association of Chorioamnionitis With Bronchopulmonary Dysplasia Among Preterm Infants: A Systematic Review, Meta-analysis, and Metaregression.
- Bronchopulmonary dysplasia
- Delivery room and stabilisation
- Early-onset sepsis
- Infection
- Medical
- Preterm stabilisation
- Respiratory
- Respiratory distress syndrome and surfactant
This paper is from 2019, more than five years ago. Newer evidence may have been published since.
Summary
This systematic review, meta-analysis and metaregression of 158 observational studies (over 244,000 preterm infants) examines the association between chorioamnionitis exposure and bronchopulmonary dysplasia, defined at day 28 or 36 weeks' postmenstrual age. Chorioamnionitis was associated with a higher risk of BPD. Metaregression explored confounders including gestational age, respiratory distress syndrome, antenatal corticosteroids and sepsis, suggesting the association may be modulated by gestational age and RDS risk. It is relevant to neonatal clinicians considering perinatal risk factors for chronic lung disease of prematurity.
Summary written for NICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
The full text of this openly licensed paper is available to NICUlearn members, and Neeky can answer questions from it.
Guidelines are shown for education. Follow your unit's own guidance and senior advice.