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Evidence · Systematic review or meta-analysis

Development of locally relevant clinical guidelines for procedure-related neonatal analgesic practice in Kenya: a systematic review and meta-analysis.

Systematic review or meta-analysisThe Lancet Child & Adolescent Health2020Over 5 years oldFull text
  • Breast milk and breastfeeding
  • Comfort and nursing care
  • Family-integrated care
  • Medical
  • Nursing
  • Pain and comfort

This paper is from 2020, more than five years ago. Newer evidence may have been published since.

Summary

This systematic review and meta-analysis of randomised trials informed the development of Kenya's first evidence-based guidelines for managing routine procedure-related pain in neonates in low-resource hospital settings. A panel of 17 Kenyan health-care professionals used the GRADE framework alongside local context to formulate recommendations. High-certainty evidence supported breastfeeding and oral sugar solutions over placebo, with moderate certainty for expressed breastmilk. The panel recommended breastfeeding as first-line analgesia, with expressed breastmilk or oral sugar for infants unable to breastfeed, plus parental presence, skin-to-skin care or non-nutritive sucking; the guidelines were adopted by the Kenyan Ministry of Health.

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