Evidence · Randomised trial
Effect of Treatment of Clinical Seizures vs Electrographic Seizures in Full-Term and Near-Term Neonates: A Randomized Clinical Trial.
- Hypoxic-ischaemic encephalopathy and cooling
- Medical
- Neurodevelopmental follow-up
- Neurology
- Nursing
- Seizures
Summary
This randomised clinical trial in tertiary neonatal intensive care units compared treating both aEEG-detected electrographic and clinical seizures with treating clinical seizures only, in encephalopathic neonates of 35 weeks' gestation or more. Most infants had moderate to severe hypoxic-ischaemic encephalopathy. The primary outcome was death or severe disability at 2 years, with MRI brain injury, feeding and Bayley-III domain scores as secondary outcomes. Treating electrographic seizures with currently used anticonvulsants did not significantly reduce death or disability, and cognitive scores were lower in the electrographic treatment group.
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- Open (Creative Commons)
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