Evidence · Research paper
Acute Kidney Injury and Neurodevelopmental Outcomes in Extremely Premature Neonates: A Secondary Analysis of a Randomized Clinical Trial.
- Acute kidney injury
- Medical
- Metabolic, endocrine and renal
- Neurodevelopmental follow-up
- Neurology
Summary
Secondary analysis of the PENUT trial cohort of extremely preterm infants born at 24 to 27 weeks' gestation across 30 US neonatal units, examining the association between acute kidney injury and neurodevelopmental outcomes at 22 to 26 months' corrected age. AKI occurred in 39% of survivors with follow-up and was associated with higher odds of death or moderate to severe neurodevelopmental impairment and lower cognitive scores on the Bayley-III. Neither the stage nor the timing of AKI was associated with impairment. The findings highlight AKI as a marker of neurodevelopmental risk relevant to follow-up planning.
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- Open (Creative Commons)
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