Evidence · Systematic review or meta-analysis
Prognostic Value of Clinical Tests in Neonates With Hypoxic-Ischemic Encephalopathy Treated With Therapeutic Hypothermia: A Systematic Review and Meta-Analysis.
- Hypoxic-ischaemic encephalopathy and cooling
- Medical
- Neurodevelopmental follow-up
- Neurology
This paper is from 2020, more than five years ago. Newer evidence may have been published since.
Summary
This systematic review and meta-analysis assesses the prognostic accuracy of clinical tests performed in the early postnatal period for predicting neurological outcome at 18 months to 3 years in near-term and term infants with HIE treated with therapeutic hypothermia. It pooled 26 studies including 1,458 infants and evaluated MRI, multichannel EEG, aEEG background pattern and somatosensory evoked potentials. MRI within two weeks of birth and EEG or aEEG showed promise as predictors of adverse outcome, whereas evidence for SEPs was weaker. The authors call for larger prospective studies and longer follow-up into later childhood.
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- Licence:
- Open (Creative Commons)
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