Evidence · Randomised trial
A pilot study of less invasive surfactant administration in very preterm infants in a Chinese tertiary center.
- Bronchopulmonary dysplasia
- CPAP and high flow
- Eyes and hearing
- Mechanical ventilation
- Medical
- Nursing
- Respiratory
- Respiratory distress syndrome and surfactant
- Retinopathy of prematurity
This paper is from 2015, more than five years ago. Newer evidence may have been published since.
Summary
This single-centre pilot randomised study from a Chinese tertiary unit compared less invasive surfactant administration (LISA) via a thin catheter on nasal CPAP with conventional endotracheal instillation in 90 preterm infants of 28-32 weeks' gestation with respiratory distress. Surfactant was successfully given in nearly all infants by either method. Durations of mechanical ventilation and nCPAP were shorter with LISA, without differences in early ventilation rate, oxygen duration, mortality, BPD, IVH, ROP or NEC. The authors conclude LISA is feasible and potentially effective, warranting larger trials.
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- Licence:
- Open (Creative Commons)
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