Evidence · Systematic review or meta-analysis
Evidence-based interventions to reduce mortality among preterm and low-birthweight neonates in low-income and middle-income countries: a systematic review and meta-analysis.
- Cord management
- Delivery room and stabilisation
- Education and simulation
- Families and professional practice
- Family-integrated care
- Infection
- Infection prevention
- Medical
- Newborn life support
- Nursing
- Postnatal and transitional care
- Preterm stabilisation
- Skin care
Summary
Systematic review and meta-analysis of randomised trials reporting neonatal mortality among preterm and low-birthweight infants in low- and middle-income countries, covering 39 interventions across 21 countries. High-quality evidence supported mortality reductions with antenatal corticosteroids, chlorhexidine cord and skin cleansing, early BCG vaccination, community kangaroo mother care and home-based newborn care. Training birth attendants in essential newborn care or resuscitation showed no effect on perinatal or 7-day mortality. The authors call for updating WHO guidance and examine barriers and facilitators to implementation.
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- Licence:
- Open (Creative Commons)
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