Evidence · Systematic review or meta-analysis
Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
- Anaemia and transfusion
- Jaundice and haematology
- Jaundice and phototherapy
- Medical
- Postnatal and transitional care
- Transitional care
Summary
Systematic literature review of the antenatal treatment landscape and outcomes of Rh(D)- and Kell-mediated haemolytic disease of the fetus and newborn (HDFN). It covers prevalence, treatment patterns, clinical outcomes, efficacy and mortality, drawing largely on case reports and case series. Intrauterine transfusion was the most commonly reported antenatal treatment, with associated risks including hydrops and fetal mortality, and most births occurred at late preterm gestation. Evidence gaps and priorities for future research are identified.
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- Licence:
- Open (Creative Commons)
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