Evidence · Systematic review or meta-analysis
Effect of therapeutic hypothermia on renal and myocardial function in asphyxiated (near) term neonates: A systematic review and meta-analysis.
- Acute kidney injury
- Cardiovascular
- Hypoxic-ischaemic encephalopathy and cooling
- Medical
- Metabolic, endocrine and renal
- Neurodevelopmental follow-up
- Neurology
Summary
This systematic review and meta-analysis examines the short- and long-term effects of therapeutic hypothermia on renal and myocardial function in (near) term neonates with perinatal asphyxia. Nine studies on renal outcomes were included, all reporting acute kidney injury incidence, which was lower in cooled infants than controls. No studies addressed long-term renal or myocardial outcomes, though most short-term studies suggested reduced cardiac biomarkers and less myocardial dysfunction on ECG and echocardiography. The findings suggest potential renoprotective and cardioprotective effects of cooling and highlight the need for long-term follow-up research.
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- Open (Creative Commons)
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