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Evidence · Review article

Treatment of Urinary Tract Infections in Neonates and Young Infants: Evidence and Recommendations.

Review articleAntibiotics (Basel, Switzerland)2026Full text
  • Infection
  • Late-onset sepsis
  • Medical
  • Metabolic, endocrine and renal

Summary

This narrative review synthesises evidence on antibiotic treatment of urinary tract infection in neonates (0-28 days) and young infants (29-90 days), including preterm infants. It covers predominant uropathogens such as E. coli and ESBL-producing organisms, the duration of intravenous therapy, intravenous-to-oral step-down and the importance of excluding meningitis. It frames its recommendations around antimicrobial stewardship and highlights major evidence gaps, including empiric regimen selection and management of premature infants.

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