Evidence · Systematic review or meta-analysis
Early Caffeine Use in Very Low Birth Weight Infants and Neonatal Outcomes: A Systematic Review and Meta-Analysis.
- Apnoea of prematurity
- Bronchopulmonary dysplasia
- Medical
- Necrotising enterocolitis
- Respiratory
This paper is from 2015, more than five years ago. Newer evidence may have been published since.
Summary
This systematic review and meta-analysis compares early (days 0-2) versus late (day 3 onwards) caffeine citrate in very low birth weight infants, pooling five mainly observational studies with over 59,000 participants. Early caffeine was associated with lower mortality, bronchopulmonary dysplasia, and the combined outcome of BPD or death. It was not associated with an increased risk of necrotising enterocolitis or surgical NEC. It is relevant to clinicians managing apnoea of prematurity and respiratory care in preterm infants.
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- Licence:
- Open (Creative Commons)
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