Evidence · Research paper
Serum copeptin and neuron specific enolase are markers of neonatal distress and long-term neurodevelopmental outcome.
- Hypoxic-ischaemic encephalopathy and cooling
- Medical
- Neurodevelopmental follow-up
- Neurology
This paper is from 2017, more than five years ago. Newer evidence may have been published since.
Summary
Observational study of serial serum copeptin and neuron-specific enolase levels over the first 168 hours in 75 term neonates with hypoxic-ischaemic encephalopathy treated with therapeutic hypothermia, plus a small normothermic subgroup from the TOBY cohort. Biomarker levels correlated with early blood-gas parameters and were higher in infants with poor neurodevelopmental outcome on Bayley assessment at two years. Copeptin was lower in cooled than normothermic infants. The authors propose both markers as potential early prognostic biomarkers in HIE.
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- Open (Creative Commons)
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