Evidence · Systematic review or meta-analysis
Active Treatment vs Expectant Management of Patent Ductus Arteriosus in Preterm Infants: A Meta-Analysis.
- Bronchopulmonary dysplasia
- Cardiovascular
- Medical
- Patent ductus arteriosus
- Respiratory
Summary
This systematic review and meta-analysis of 10 randomised trials (2035 infants born before 33 weeks) compares active treatment with expectant management of haemodynamically significant patent ductus arteriosus in preterm infants. Primary outcomes were death or moderate to severe bronchopulmonary dysplasia, death at 36 weeks, and moderate to severe BPD; secondary outcomes included IVH, PVL, ROP and NEC. Active treatment in the first two weeks was associated with a higher incidence of death or moderate to severe BPD and higher mortality than expectant management. The authors call for further research to inform revision of PDA management protocols.
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- Open (Creative Commons)
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