Evidence · Randomised trial
Randomised crossover trial of neurally adjusted ventilatory assist (NAVA) for neonates with congenital diaphragmatic hernias: the NAN-C study.
- Congenital diaphragmatic hernia
- Mechanical ventilation
- Medical
- Nursing
- Respiratory
- Surgical conditions
Summary
This dual-centre randomised crossover trial compared neurally adjusted ventilatory assist (NAVA) with assist control ventilation in post-operative infants with congenital diaphragmatic hernia. Nine mostly term infants completed 4-hour periods on each mode, with oxygenation index, airway pressures, diaphragm electrical activity and tidal volumes compared. NAVA was associated with improved oxygenation and lower ventilatory pressures, peak Edi and tidal volumes. Two infants could not continue because of a low Edi signal, highlighting practical limitations.
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- Licence:
- Open (Creative Commons)
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