Evidence · Systematic review or meta-analysis
Serum Cystatin C as a predictor of acute kidney injury in neonates: a meta-analysis.
- Acute kidney injury
- Medical
- Metabolic, endocrine and renal
Summary
This meta-analysis of twelve studies evaluates the diagnostic accuracy of serum cystatin C for predicting acute kidney injury in neonates. Literature from English and Chinese databases was pooled, with study quality assessed using QUADAS-2 and heterogeneity explored by meta-regression and subgroup analysis. Serum cystatin C showed good pooled sensitivity, specificity and area under the curve for neonatal AKI. The authors suggest it is a candidate biomarker, though optimal cut-off levels need confirmation in large prospective studies.
Summary written for NICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
The full text of this openly licensed paper is available to NICUlearn members, and Neeky can answer questions from it.
Guidelines are shown for education. Follow your unit's own guidance and senior advice.